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Chemical Structure : HG-10-102-01
CAS No.: 1351758-81-0
Catalog No.: PC-22264Not For Human Use, Lab Use Only.
HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 and LRRK2 G2019S mutant with IC50 of 20.3 nM and 3.2 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 and LRRK2 G2019S mutant with IC50 of 20.3 nM and 3.2 nM, respectively.
HG-10-102-01 is capable of inhibiting LRRK2 phosphorylation in mouse brain.
HG-10-102-01 maintains inhibition of the A2016T mutation (IC50=153.7 nM), which induces dramatic resistance to LRRK2-IN-1.
HG-10-102-01 (0.03-1 uM) induced a dose-dependent inhibition of Ser910 and Ser935 phosphorylation in both wild-type LRRK2 and LRRK2[G2019S] stably transfected into HEK293 cells.
HG-10-102-01 also induced dephosphorylation of Ser910 and Ser935 at a concentration of 1-3 μM in the drug-resistant LRRK2[A2016T + G2019S] and LRRK2[A2016T] mutants.
HG-10-102-01 is capable of inhibiting Ser910 and Ser935 phosphorylation in mouse brain following intraperitoneal delivery of doses as low as 50 mg/kg.
| M.Wt | 377.83 | |
| Formula | C17H20ClN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(4-((5-chloro-4-(methylamino)pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone |
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1. Choi HG, et al. ACS Med Chem Lett. 2012 Aug 9;3(8):658-662.
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