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Chemical Structure : HG106
CAS No.: 928712-10-1
Catalog No.: PC-73129Not For Human Use, Lab Use Only.
HG106 (HG 106) is a potent, selective SLC7A11 inhibitor, selectively kills KRAS-mutant lung adenocarcinoma (LUAD) cells.
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|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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HG106 (HG 106) is a potent, selective SLC7A11 inhibitor, selectively kills KRAS-mutant lung adenocarcinoma (LUAD) cells.
HG106 exerts substantial cytotoxic effects on KRAS-mutant H441 cells, which are strikingly reduced by addition of β-mercaptoethanol and l-cysteine.
HG106 preferentially decreases the viability of KRAS-mutant LUAD cells (A549 cells IC50=3.7 uM), dose-dependently reduces the oxygen consumption rate and disrupted MMP in A549 and H441 cells.
HG106 significantly induced apoptosis in KRAS-mutant LUAD cells and inhibited colony formation.
HG106 exhibits potent in vivo efficacy in a patient-derived xenograft (PDX) model of LUAD harboring a G12V mutation in KRAS.
| M.Wt | 316.745 | |
| Formula | C15H13ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-chloro-N-(2-(4-methoxyphenyl)-2H-benzo[d][1,2,3]triazol-5-yl)acetamide |
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1. Hu K, et al. J Clin Invest. 2020 Apr 1;130(4):1752-1766.
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