Chemical Structure : HIF inhibitor 3.2.16
CAS No.:
3112734-60-5
HIF inhibitor 3.2.16
Catalog No.: PC-26485Not For Human Use, Lab Use Only.
HIF inhibitor 3.2.16 is a potent, dual HIF-1/2 inhibitor with MST Kd of 47.4 nM for HIF-1α, inhibits the interaction of HIF-1α and HIF-2α with HIF-1β with IC50 of 110 nM and 62 nM in immunoblot assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HIF inhibitor 3.2.16 is a potent, dual HIF-1/2 inhibitor with MST Kd of 47.4 nM for HIF-1α, inhibits the interaction of HIF-1α and HIF-2α with HIF-1β with IC50 of 110 nM and 62 nM in immunoblot assays.
3.2.16 enhances the antitumor activity of anti-CTLA-4 antibody in CRC.
3.2.16 enhances response to α-CTLA-4 in melanoma and prostate cancer models.
3.2.16 decreases mRNA expression of markers of angiogenesis (Angptl4, Vegf), T cell exhaustion (Lag-3, Pd-1, Tim-3), and other mediators of immunosuppression (Ca9, Cd47, Cd73, Glut1, Il-6, Pd-l1, Vegf) in E0771 tumors from mice.
Physicochemical Properties
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M.Wt
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327.43
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Formula
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C19H25N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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cis-3-(6-((2-(2-ethylphenoxy)ethyl)(methyl)amino) pyrimidin-4-yl)cyclobutan-1-ol
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References
1. Salman S, et al. J Exp Med. 2026 May 4;223(5):e20251009.
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