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HL001

Chemical Structure : HL001

CAS No.: 1186371-31-2

HL001 (HL 001)

Catalog No.: PC-61324Not For Human Use, Lab Use Only.

HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression.
    HL001 stabilizes p53 through inhibiting the MDM2-mediated p53 ubiquitination, and downregulates G3BP1 and induces ROS and DNA damage.
    HL001 selectively suppresses tumor growth in p53 wild-type NSCLC harboring p53-72R through disrupting interaction between MDM2 and p53-72R in a CypA-dependent manner.
    HL001 synergistically enhance tumor regression in orthotopic NSCLC mouse model combined with cisplatin.

    Physicochemical Properties

    M.Wt 360.369
    Formula C21H16N2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-((9H-fluoren-9-yl)carbamoyl)-2,6-dihydroxybenzamide

    References

    1. Lu W, et al. Oncogene. 2017 Aug 17;36(33):4719-4731.

    2. Ni S, et al. J Med Chem. 2009 Sep 10;52(17):5295-8.

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