I-2906 |CAS:331963-29-2 Probechem Biochemicals

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Chemical Structure : I-2906

CAS No.: 331963-29-2

I-2906 (I 2906;I2906)

Catalog No.: PC-45967Not For Human Use, Lab Use Only.

A novel isocitrate lyase (ICL) inhibitor that displays showed excellent anti-Mycobacterium tuberculosisl activities and low cytotoxicity.

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Biological Activity

A novel isocitrate lyase (ICL) inhibitor that displays showed excellent anti-Mycobacterium tuberculosisl activities and low cytotoxicity; shows good activity against M. tuberculosis H37Ra with MIC of 0.5 ug/ml; significantlt reduces bacterial loads of both lungs and spleen in a murine model.

Bacterial Infection

Preclinical

Physicochemical Properties

M.Wt	443.579
Formula	C25H37N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Quinolinecarboxylic acid, 1-ethyl-1,2-dihydro-4-hydroxy-2-oxo-, 2-(1-oxotridecyl)hydrazide

References

1. Lu J, et al. Pharmacology. 2010;85(6):365-71.

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I-2906 (I 2906;I2906)

Biological Activity

Physicochemical Properties

References

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