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Chemical Structure : IC-87201
CAS No.: 866927-10-8
Catalog No.: PC-42163Not For Human Use, Lab Use Only.
IC-87201 (IC87201) is a small molecule inhibitor of PSD-95/nNOS interaction with IC50 of 31 uM, without inhibiting nNOS catalytic activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | $588 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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IC-87201 (IC87201) is a small molecule inhibitor of PSD-95/nNOS interaction with IC50 of 31 uM, without inhibiting nNOS catalytic activity.
IC-87201 dose-dependently blocks NMDA-induced increase in cGMP production in hippocampal cultures with IC50 of 2.7 uM.
IC-87201 inhibits NMDA-induced thermal hyperalgesia in mice with no effect on acute pain thresholds or motor coordination, also reverses mechanical allodynia induced by chronic constriction of the sciatic nerve.
| M.Wt | 309.1507 | |
| Formula | C13H10Cl2N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 28 mg/mL |
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| Chemical Name/SMILES |
Phenol, 2-[(1H-benzotriazol-6-ylamino)methyl]-4,6-dichloro- |
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1. Florio SK, et al. Br J Pharmacol. 2009 Sep;158(2):494-506.
2. Doucet MV, et al. Neuropsychopharmacology. 2013 Jul;38(8):1575-84.
3. Bach A, et al. Sci Rep. 2015 Jul 16;5:12157.
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