Catalog No.: PC-63360Not For Human Use, Lab Use Only.
ITZ-1 is a client-selective Hsp90 inhibitor that efficiently induces heat shock factor 1 (HSF1) activation, selectively inhibits IL-1β-induced MMP-13 production (IC50=0.51 uM) via inhibition of ERK activation.
ITZ-1 is a client-selective Hsp90 inhibitor that efficiently induces heat shock factor 1 (HSF1) activation, selectively inhibits IL-1β-induced MMP-13 production (IC50=0.51 uM) via inhibition of ERK activation.
ITZ-1 causes mild Raf-1 degradation, but scarcely induces degradation of a broad range of Hsp90 client proteins by binding to the Hsp90 C terminus.
ITZ-1 suppresses both IL-1β-induced proteoglycan and collagen release from bovine nasal cartilage in vitro and suppresses intra-articular infusion of IL-1β-induced cartilage proteoglycan degradation in rat knee joints.
