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Chemical Structure : Ifidancitinib
CAS No.: 1236667-40-5
Catalog No.: PC-49397Not For Human Use, Lab Use Only.
Ifidancitinib (ATI-502, ATI-50002, R507) is a potent and selective next-generation JAK1/3 inhibitor, potently inhibits γc cytokine signaling.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Ifidancitinib (ATI-502, ATI-50002, R507) is a potent and selective next-generation JAK1/3 inhibitor, potently inhibits γc cytokine signaling.
Ifidancitinib strongly inhibited IL-2-stimulated STAT5 phosphorylation in mouse T cells.
Ifidancitinib also exhibited potent inhibitory effects on JAK1/2-mediated IFN-γ signaling.
Ifidancitinib treatment significantly reduced the population of NKG2D+CD8+ T cells in a dose-dependent manner.
Ifidancitinib impaired murine T cell proliferation and human T cell function in vitro and in vivo.
Ifidancitinib prevented the onset of alopecia in alopecia areata (AA) skin grafted C3H/HeJ mice.
Ifidancitinib induced multiple co-inhibitory receptors in CD44+CD62L- CD8+ T cells.
Ifidancitinib exhibited potent anti-inflammatory effects both in vitro and in C3H/HeJ mice in vivo, suppressed IFN-γ signaling with the reduced expression of IFN-γ-dependent genes such as MHC class I, CXCL10, and CXCL11.
| M.Wt | 395.394 | |
| Formula | C20H18FN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-[[2-(4-fluoro-3-methoxy-5-methylanilino)-5-methylpyrimidin-4-yl]amino]-3H-1,3-benzoxazol-2-one |
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1. Zhenpeng Dai, et al. Front Immunol. 2022 Sep 20;13:955038.
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