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InS3-54

Chemical Structure : InS3-54

CAS No.: 328998-92-1

InS3-54 (STAT3 inhibitor)

Catalog No.: PC-62378Not For Human Use, Lab Use Only.

InS3-54 is a small molecule STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    InS3-54 is a small molecule STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3.
    InS3-54 preferentially suppresses proliferation of cancer over non-cancer cells and inhibits migration and invasion of malignant cells.
    InS3-54 selectively inhibits STAT3 binding to DNA without affecting the activation and dimerization of STAT3.
    InS3-54 inhibits expression of STAT3 downstream target genes and STAT3 binding to chromatin in situ.

    Physicochemical Properties

    M.Wt 412.401
    Formula C24H16N2O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (E)-4-(3-(4-nitrobenzylidene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid

    References

    1. Huang W, et al. ACS Chem Biol. 2014 May 16;9(5):1188-96.

    2. Huang W, et al. Oncogene. 2016 Feb 11;35(6):783-92.

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