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Ipidacrine hydrochloride hydrate

Chemical Structure : Ipidacrine hydrochloride hydrate

CAS No.: 118499-70-0

Ipidacrine hydrochloride hydrate (Amiridine;NIK 247)

Catalog No.: PC-62461Not For Human Use, Lab Use Only.

Ipidacrine hydrochloride hydrate is a reversible acetylcholinesterase (AChE) inhibitor that directly stimulates impulse transmission in the central nervous system and neuromuscular synapses by blocking membrane potassium channels.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Ipidacrine hydrochloride hydrate is a reversible acetylcholinesterase (AChE) inhibitor that directly stimulates impulse transmission in the central nervous system and neuromuscular synapses by blocking membrane potassium channels; enhances not only choline, but also adrenaline, serotonin, histamine, and oxytocin effects on smooth muscle.

Alzheimer Disease

Phase 3 Discontinued

Physicochemical Properties

M.Wt 242.747
Formula C12H19ClN2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine hydrochloride hydrate

References

1. Nabeshima T, et al. Eur J Pharmacol. 1988 Sep 23;154(3):263-9.

2. Onodera K, et al. Nihon Shinkei Seishin Yakurigaku Zasshi. 1998 Apr;18(2):33-7.

3. Kojima J, et al. Gen Pharmacol. 1998 Aug;31(2):297-300.

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