Catalog No.: PC-23855Not For Human Use, Lab Use Only.
Irbesartan (SR 47436) is a potent, selective nonpeptide AT1 angiotensin II receptor (AT1 receptor) antagonist, inhibits [125I]AII binding to AT1 subtype receptors in rat liver membrane with IC50 of 1.7 nM, with no effect on AT2 subtypes.
Irbesartan (SR 47436) is a potent, selective nonpeptide AT1 angiotensin II receptor (AT1 receptor) antagonist, inhibits [125I]AII binding to AT1 subtype receptors in rat liver membrane with IC50 of 1.7 nM, with no effect on AT2 subtypes. Irbesartan (SR 47436) inhibits contractions induced by 10 nM AII (IC50 = 4.0 nM) in rabbit aorta. Irbesartan (SR 47436) is lack of activity (IC50 > 10 microM) on various other receptors, ionic channels and antiports and rabbit aorta contracted by norepinephrine and KCl, and lack of inhibition of renin and converting enzyme. Irbesartan (SR 47436) antagonized the AII-pressor response in a dose-related manner in conscious rats.
