You are here:Home-Chemical Inhibitors & Agonists-JAK/STAT Signaling-JAK-JAK3-IN-2
JAK3-IN-2

Chemical Structure : JAK3-IN-2

CAS No.: 1443235-95-7

JAK3-IN-2 (JAK3 inhibitor 2)

Catalog No.: PC-60690Not For Human Use, Lab Use Only.

JAK3-IN-2 is a potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM.

Packing Price Stock Quantity
10 mg $118 In stock
25 mg $198 In stock
50 mg $298 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JAK3-IN-2 is a potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM.
JAK3-IN-2 dispalys >4,300-fold selectivity over JAK1, JAK2 and TYK2, and other kinases BMX, EGFR, ITK and BTK.
JAK3-IN-2 blocks cytokine signaling through JAK3, but not through other JAK family enzymes.
JAK3-IN-2 inhibits IL-7 induced pSTAT5 in CD3+, CD8+ T cells with IC50 of 280 nM.
JAK3-IN-2 sufficiently blocks the development of inflammation in a rat model of rheumatoid arthritis, while sparing hematopoiesis.

Physicochemical Properties

M.Wt 350.378
Formula C19H18N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

100 mM in DMSO

Chemical Name/SMILES

ethyl 4-(3-methacrylamidophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

References

1. Elwood F, et al. J Pharmacol Exp Ther. 2017 May;361(2):229-244.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: