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Chemical Structure : JAK3-IN-2
CAS No.: 1443235-95-7
Catalog No.: PC-60690Not For Human Use, Lab Use Only.
JAK3-IN-2 is a potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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JAK3-IN-2 is a potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM.
JAK3-IN-2 dispalys >4,300-fold selectivity over JAK1, JAK2 and TYK2, and other kinases BMX, EGFR, ITK and BTK.
JAK3-IN-2 blocks cytokine signaling through JAK3, but not through other JAK family enzymes.
JAK3-IN-2 inhibits IL-7 induced pSTAT5 in CD3+, CD8+ T cells with IC50 of 280 nM.
JAK3-IN-2 sufficiently blocks the development of inflammation in a rat model of rheumatoid arthritis, while sparing hematopoiesis.
| M.Wt | 350.378 | |
| Formula | C19H18N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO |
|
| Chemical Name/SMILES |
ethyl 4-(3-methacrylamidophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate |
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1. Elwood F, et al. J Pharmacol Exp Ther. 2017 May;361(2):229-244.
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