Chemical Structure : JBI-097
CAS No.:
2738306-38-0
JBI-097
Catalog No.: PC-24003Not For Human Use, Lab Use Only.
JBI-097 is a potent, dual LSD1/HDAC6 inhibitor with IC50 of 6/48 nM respectively, also inhibits HDAC8 (IC50=71 nM), does not inhibit other HDACs.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JBI-097 is a potent, dual LSD1/HDAC6 inhibitor with IC50 of 6/48 nM respectively, also inhibits HDAC8 (IC50=71 nM), does not inhibit other HDACs.
JBI-097 inhibited the proliferation of haematological cancers like acute myeloid leukaemia (AML), chronic myeloid leukaemia (CML), erythroleukaemia, and multiple myeloma with stronger potency with EC50 of 0.002-1.5 uM (MM1.S, EC50=2 nM).
JBI-097 also showed strong modulation of HDAC6 and LSD1 specific biomarkers, alpha-tubulin, CD86, CD11b, and GFi1b.
JBI-097 showed a stronger effect in erythroleukemia, multiple myeloma xenograft models, and in CT-26 syngeneic model.
JBI-097 also showed efficacy as monotherapy and additive or synergistic efficacy in combination with the standard of care or with immune checkpoint inhibitors.
Physicochemical Properties
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M.Wt
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407.56
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Formula
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C25H33N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-hydroxy-4-(3-(4-((((1S,2R)-2-phenylcyclopropyl)amino)methyl)piperidin-1-yl)propyl)benzamide
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References
1. Gajendran C, et al. PLoS One. 2023 Jan 3;18(1):e0279063.
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