Chemical Structure : JD-5006
CAS No.:
1148142-42-0
JD-5006
(JD5006)
Catalog No.: PC-20518Not For Human Use, Lab Use Only.
JD-5006 is a potent, selective and peripherally restricted cannabinoid-1 (CB1) receptor blocker with IC50 of 18 nM, does not inhibit CB2 receptor (IC50>5000 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JD-5006 is a potent, selective and peripherally restricted cannabinoid-1 (CB1) receptor blocker with IC50 of 18 nM, does not inhibit CB2 receptor (IC50>5000 nM).
JD-5006 was also characterized as an inverse agonist in forskolin-stimulated CHO cells over- expressing CB1-receptors by its ability to affect cAMP with EC50 of 46 nM.
JD-5006 showed little brain presence as indicated by tissue distribution and receptor occupancy studies.
JD-5006 (20 mg/kg PO) normalized triglyceride levels, liver mass and ALT as well a beneficial effect on glycemic control in model of diabetes.
Physicochemical Properties
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M.Wt
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530.42
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Formula
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C24H21Cl2N5O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(N)CN/C(N1N=C(C2=CC=C(Cl)C=C2)C(C3=CC=CC=C3)C1)=N\S(=O)(C4=CC=C(Cl)C=C4)=O
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References
1. Robert J Chorvat, et al. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6173-80.
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