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Chemical Structure : JD-5006
Catalog No.: PC-20518Not For Human Use, Lab Use Only.
JD-5006 is a potent, selective and peripherally restricted cannabinoid-1 (CB1) receptor blocker with IC50 of 18 nM, does not inhibit CB2 receptor (IC50>5000 nM).
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JD-5006 is a potent, selective and peripherally restricted cannabinoid-1 (CB1) receptor blocker with IC50 of 18 nM, does not inhibit CB2 receptor (IC50>5000 nM).
JD-5006 was also characterized as an inverse agonist in forskolin-stimulated CHO cells over- expressing CB1-receptors by its ability to affect cAMP with EC50 of 46 nM.
JD-5006 showed little brain presence as indicated by tissue distribution and receptor occupancy studies.
JD-5006 (20 mg/kg PO) normalized triglyceride levels, liver mass and ALT as well a beneficial effect on glycemic control in model of diabetes.
| M.Wt | 530.42 | |
| Formula | C24H21Cl2N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Robert J Chorvat, et al. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6173-80.
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