Chemical Structure : JG-023
Catalog No.: PC-23951Not For Human Use, Lab Use Only.
JG-023 is a novel isoform selective small-molecule inhibitor of HSPA5/6 with IC50 of <0.5 uM for both, shows selectivity for HSPA5 (BiP or GRP78) and HSPA6.
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JG-023 is a novel isoform selective small-molecule inhibitor of HSPA5/6 with IC50 of <0.5 uM for both, shows selectivity for HSPA5 (BiP or GRP78) and HSPA6.
JG-023 induced pro-apoptotic UPR signaling and enhanced the cytotoxic effects of proteasome inhibitors and other UPR-inducing drugs in CTCL but not normal T cells.
JG-023 also selectively suppressed the production of Th2 cytokines in CTCL and normal CD4+ T cells.
M.Wt | 384.50 | |
Formula | C20H24N4O2S | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Nadia St Thomas, et al. Biomolecules. 2025 Jan 7;15(1):76.
2. Ambrose A.J., et al. J. Med. Chem. 2023;66:677–694.
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