Catalog No.: PC-62492Not For Human Use, Lab Use Only.
JG-98 is an allosteric Hsp70 inhibitor, displays >3-fold more active, greater stability than MKT-077 against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50 of 0.4 uM and 0.7 uM, respectively).
JG-98 is an allosteric Hsp70 inhibitor, displays >3-fold more active, greater stability than MKT-077 against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50 of 0.4 uM and 0.7 uM, respectively).
JG-98 strongly affects autophagic flux, increases p62 oligomerization and reduces p62 monomer.
JG-98 destabilizes FoxM1 and relieved suppression of downstream effectors, including p21 and p27.
