Catalog No.: PC-21982Not For Human Use, Lab Use Only.
JNJ-1661010 (Takeda-25) is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 34 and 33 nM for rat FAAH and human FAAH, respectively.
JNJ-1661010 (Takeda-25) is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 34 and 33 nM for rat FAAH and human FAAH, respectively. JNJ-1661010 is >100-fold preferentially selective for FAAH-1 when compared to FAAH-2. JNJ-1661010 dose-dependently increases arachidonoyl ethanolamide, oleoyl ethanolamide, and palmitoyl ethanolamide in the rat brain. JNJ-1661010 attenuates tactile allodynia in the rat mild thermal injury model of acute tissue damage and in the rat spinal nerve ligation (Chung) model of neuropathic pain. JNJ-1661010 also diminishes thermal hyperalgesia in the inflammatory rat carrageenan paw model.
