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Chemical Structure : JNJ-1661010
CAS No.: 681136-29-8
Catalog No.: PC-21982Not For Human Use, Lab Use Only.
JNJ-1661010 (Takeda-25) is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 34 and 33 nM for rat FAAH and human FAAH, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $358 | In stock | |
| 200 mg | Get quote |
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JNJ-1661010 (Takeda-25) is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 34 and 33 nM for rat FAAH and human FAAH, respectively.
JNJ-1661010 is >100-fold preferentially selective for FAAH-1 when compared to FAAH-2.
JNJ-1661010 dose-dependently increases arachidonoyl ethanolamide, oleoyl ethanolamide, and palmitoyl ethanolamide in the rat brain.
JNJ-1661010 attenuates tactile allodynia in the rat mild thermal injury model of acute tissue damage and in the rat spinal nerve ligation (Chung) model of neuropathic pain.
JNJ-1661010 also diminishes thermal hyperalgesia in the inflammatory rat carrageenan paw model.
| M.Wt | 365.46 | |
| Formula | C19H19N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide |
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1. Keith JM, et al. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4838-43.
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