Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : JNJ-42253432
CAS No.: 1428327-35-8
Catalog No.: PC-60767Not For Human Use, Lab Use Only.
JNJ-42253432 is a potent, selective, CNS-penetrant P2X7 antagonist with pKi of 9.1 and 7.9 for rat and huamn P2X7 channel, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $428 | In stock | |
| 10 mg | $728 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
JNJ-42253432 is a potent, selective, CNS-penetrant P2X7 antagonist with pKi of 9.1 and 7.9 for rat and huamn P2X7 channel, respectively.
JNJ-42253432 does not block calcium flux via human P2X1, P2X2, P2X3, P2X2/P2X3, and P2X4 at 10 uM.
JNJ-42253432 attenuates both ATP- and Bz-ATP-induced currents from hP2X7-1321N1 cells with similar potencies (pEC50=7.0).
JNJ-42253432 blocks the release of IL-1β induced by Bz-ATP in freely moving rat brain, also increases serotonin levels.
JNJ-42253432 attenuates amphetamine-induced hyperactivity in vivo.
| M.Wt | 446.639 | |
| Formula | C28H38N4O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-methyl-N-([1-(4-phenylpiperazin-1-yl)cyclohexyl]methyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide |
|
1. Lord B, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):628-41.
2. Amhaoul H, et al. Neuropharmacology. 2016 Jun;105:175-185.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
