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Chemical Structure : JNJ-47965567
Catalog No.: PC-63425Not For Human Use, Lab Use Only.
JNJ-47965567 is a potent, selective, centrally permeable P2X7 receptor antagonist with pKi of 7.9 and 8.7 for human and rat P2X7, respectively.
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JNJ-47965567 is a potent, selective, centrally permeable P2X7 receptor antagonist with pKi of 7.9 and 8.7 for human and rat P2X7, respectively; attenuates IL-1β release with pEC50 of 6.7 (human blood), 7.5 (human monocytes) and 7.1 (rat microglia); exhibits target engagement in rat brain with brain EC50 of 78 ± 19 ng/ml, as well as functional block of Bz-ATP induced IL-1β release; attenuateas amphetamine-induced hyperactivity and exhibits modest, yet significant efficacy in the rat model of neuropathic pain.
| M.Wt | 488.65 | |
| Formula | C28H32N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bhattacharya A, et al. Br J Pharmacol. 2013 Oct;170(3):624-40.
2. Jimenez-Pacheco A, et al. J Neurosci. 2016 Jun 1;36(22):5920-32.
3. Letavic MA, et al. ACS Med Chem Lett. 2013 Mar 12;4(4):419-22.
4. Rodriguez-Alvarez N, et al. Neuropharmacology. 2017 Apr;116:351-363.
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