Chemical Structure : JNJ-64251330
CAS No.:
2230282-02-5
JNJ-64251330
(Lorpucitinib, JNJ 64251330)
Catalog No.: PC-21596Not For Human Use, Lab Use Only.
Lorpucitinib (JNJ-64251330) is potent, selective and orally bioavailable pan-JAK inhibitor with IC50 of 0.37/8.6/92/7.4 nM for JAK1/JAK2/JAK3/Tyk2 respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Lorpucitinib (JNJ-64251330) is potent, selective and orally bioavailable pan-JAK inhibitor with IC50 of 0.37/8.6/92/7.4 nM for JAK1/JAK2/JAK3/Tyk2 respectively.
Lorpucitinib (JNJ-64251330) shows comparable potency to tofacitinib in an IFNα-stimulated STAT4 (54 nM and 31 nM, respectively) and an IL-12-stimulated STAT4 (257 nM and 440 nM, respectively) assay.
Lorpucitinib (JNJ-64251330) is 5-6 fold less potent in GM-CSF-stimulated pSTAT5 (303 nM and 51 nM, respectively) and IL-2-stimulated pSTAT5 (61 nM and 12 nM, respectively) assays.
Lorpucitinib (JNJ-64251330) is a GI tract-restricted JAK inhibitor that selectively inhibited cytokine responses in colonic tissue and not in plasma.
Physicochemical Properties
|
M.Wt
|
408.51
|
|
Formula
|
C22H28N6O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-hydroxy-2-methylpropyl)acetamide
|
References
1. Kristi A Leonard, et al. J Med Chem. 2020 Mar 26;63(6):2915-2929.
Contact Us
sales@probechem.com
