Chemical Structure : JNJ-9676
CAS No.:
3026520-19-1
JNJ-9676
(JNJ 9676)
Catalog No.: PC-24314Not For Human Use, Lab Use Only.
JNJ-9676 is a potent, specific small-molecule inhibitor of SARS-CoV-2 and SARS-CoV, binds to SARS-CoV-2 M protein, reduces SARS-CoV-2 (B1 variant) production of viral RNA with EC50/EC90 of 94/132 nM respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JNJ-9676 is a potent, specific small-molecule inhibitor of SARS-CoV-2 and SARS-CoV, binds to SARS-CoV-2 M protein, reduces SARS-CoV-2 (B1 variant) production of viral RNA with EC50/EC90 of 94/132 nM respectively.
JNJ-9676 demonstrates in vitro nanomolar antiviral activity against SARS-CoV-2, SARS-CoV and sarbecovirus strains from bat and pangolin zoonotic origin
JNJ-9676 binding induces substantial conformational changes in the M protein dimer, resulting in a novel conformational state.
JNJ-9676 (25 mg per kg BID) is able to reduce the viral RNA load and infectious virus in the lung with 3.5 log10[RNA copies per mg lung] and 4 log10[TCID50 per mg lung], respectively.
Physicochemical Properties
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M.Wt
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497.51
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Formula
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C28H21F2N5O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-N-(3-cyanophenyl)-5-(4-(difluoro(phenyl)methyl)phenyl)-6-methyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-3-carboxamide
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References
1. Van Damme E, et al. Nature. 2025 Mar 26. doi: 10.1038/s41586-025-08651-6.
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