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Chemical Structure : JNJ 39758979
Catalog No.: PC-60793Not For Human Use, Lab Use Only.
A potent, selective, orally bioavailable histamine H4 receptor antagonist with Ki of 12.5 nM, >80-fold selectivity over other histamine receptors.
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A potent, selective, orally bioavailable histamine H4 receptor antagonist with Ki of 12.5 nM, >80-fold selectivity over other histamine receptors; shows dose-dependent activity in models of asthma and dermatitis, has good pharmacokinetics.
Asthma
Phase 2 Clinical
| M.Wt | 221.308 | |
| Formula | C11H19N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Savall BM, et al. J Med Chem. 2014 Mar 27;57(6):2429-39.
2. Thurmond RL, et al. J Pharmacol Exp Ther. 2014 May;349(2):176-84.
3. Kollmeier A, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):181-7.
4. Murata Y, et al. J Dermatol. 2015 Feb;42(2):129-39.
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