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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-P2X Receptor-JNJ 54166060
JNJ 54166060

Chemical Structure : JNJ 54166060

CAS No.: 1627900-41-7

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JNJ 54166060 (JNJ-54166060, JNJ54166060)

Catalog No.: PC-61123Not For Human Use, Lab Use Only.

A potent, selective and orally bioavailable P2X7 receptor with IC50 of 4 nM and 115 nM for hP2X7 and rP2X7, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JNJ 54166060 (JNJ-54166060) is a potent, selective and orally bioavailable P2X7 receptor antagonist with IC50 of 4 nM and 115 nM for hP2X7 and rP2X7, respectively.
    JNJ 54166060 also is a potent inhibitor of CYP3A with IC50 of 2 uM, exhibits dose dependent occupancy in the rat brain with an ED50 of 2.3 mg/kg.

    Physicochemical Properties

    M.Wt 438.811
    Formula C20H15ClF4N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-(2-Chloro-3 (trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-methanone

    References

    1. Swanson DM, et al. J Med Chem. 2016 Sep 22;59(18):8535-48.

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