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Chemical Structure : JNJ 54166060
Catalog No.: PC-61123Not For Human Use, Lab Use Only.
A potent, selective and orally bioavailable P2X7 receptor with IC50 of 4 nM and 115 nM for hP2X7 and rP2X7, respectively.
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JNJ 54166060 (JNJ-54166060) is a potent, selective and orally bioavailable P2X7 receptor antagonist with IC50 of 4 nM and 115 nM for hP2X7 and rP2X7, respectively.
JNJ 54166060 also is a potent inhibitor of CYP3A with IC50 of 2 uM, exhibits dose dependent occupancy in the rat brain with an ED50 of 2.3 mg/kg.
| M.Wt | 438.811 | |
| Formula | C20H15ClF4N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Swanson DM, et al. J Med Chem. 2016 Sep 22;59(18):8535-48.
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