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KDU-691

Chemical Structure : KDU-691

CAS No.: 1513879-19-0

KDU-691 (KDU691)

Catalog No.: PC-61696Not For Human Use, Lab Use Only.

KDU-691 is a potent, selective, orally active parasite PI4K inhibitor with IC50 of 1.5 nM for P. vivax PI4K (PvPI4K).

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Biological Activity

KDU-691 is a potent, selective, orally active parasite PI4K inhibitor with IC50 of 1.5 nM for P. vivax PI4K (PvPI4K)。
KDU-691 shows IC50 of 58 nM, 36 nM and 196 nM against P. falciparum (Pf, boold stages), P. yoelii (Py, schizont) and P. cynomolgi (Pc, hypnozoites) respectively。
KDU-691 shows fully protective effect against P. cynomolgi sporozoites in animal models.

Physicochemical Properties

M.Wt 419.864
Formula C22H18ClN5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-Chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]imidazo[1,2-a]pyrazine-6-carboxamide

References

1. McNamara CW, et al. Nature. 2013 Dec 12;504(7479):248-253.

2. Zeeman AM, et al. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2858-63.

3. Zou B, et al. ACS Med Chem Lett. 2014 Jul 6;5(8):947-50.

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