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KIN-1400

Chemical Structure : KIN-1400

CAS No.: 446826-86-4

KIN-1400 (KIN1400;KIN 1400)

Catalog No.: PC-70050Not For Human Use, Lab Use Only.

KIN1400 is a potent RIG-I-like receptor (RLR) agonist that triggers IRF3-dependent innate immune antiviral genes and IFN-β expression.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KIN1400 is a potent RIG-I-like receptor (RLR) agonist that triggers IRF3-dependent innate immune antiviral genes and IFN-β expression.
KIN1400 shows antiviral activity against a broad range of RNA viruses, including dengue virus, and hepatitis C virus, as well as viruses of the families Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus), and Paramyxoviridae (respiratory syncytial virus, Nipah virus).

Physicochemical Properties

M.Wt 449.476
Formula C24H17F2N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-((benzo[d]thiazol-2-ylamino)(4-(difluoromethoxy)phenyl)methyl)quinolin-8-ol

References

1. Pattabhi S, et al. J Virol. 2015 Dec 16;90(5):2372-87.

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