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Chemical Structure : KIN-1408
CAS No.: 1903800-11-2
Catalog No.: PC-45765Not For Human Use, Lab Use Only.
A small-molecule MAVS-dependent IRF3 agonist that shows antiviral activity against Flaviviridae, Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus) and Paramyxoviridae (RSVs, Nipah virus).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $280 | In stock | |
| 10 mg | $400 | In stock | |
| 50 mg | $1200 | In stock | |
| 100 mg | $1680 | In stock |
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A small-molecule MAVS-dependent IRF3 agonist that shows antiviral activity against Flaviviridae, Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus) and Paramyxoviridae (RSVs, Nipah virus); induces relocalization of pTBK1 from centrosomes to mitochondria, and increases CASP3-mediated cell death; the RIG-I-like receptor (RLR) agonist.
| M.Wt | 479.4985 | |
| Formula | C25H19F2N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 39 mg/mL |
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| Chemical Name/SMILES |
7-((4-(difluoromethoxy)phenyl)((5-methoxybenzo[d]thiazol-2-yl)amino)methyl)quinolin-8-ol |
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1. Green RR, et al. Genom Data. 2016 Feb 1;7:290-2.
2. Pattabhi S, et al. J Virol. 2015 Dec 16;90(5):2372-87.
3. Onorati M, et al. Cell Rep. 2016 Sep 6;16(10):2576-92.
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