KIRA-8 (AMG-18) is a highly potent, monoselective IRE1α kinase inhibitor with IC50 of 5.9 nM.
KIRA-8 demonstrates higher potency than KIRA7 in inhibiting XBP1 splicing in the alveolar epithelial cell line MLE12, attenuates bleomycin-induced increases in lung weight and hydroxyproline, and decreases mRNA expression of collagen 1A1 and fibronectin in murine model of pulmonary fibrosis.
