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Chemical Structure : KIRA-8
CAS No.: 1630086-20-2
Catalog No.: PC-36004Not For Human Use, Lab Use Only.
KIRA-8 (AMG-18) is a highly potent, monoselective IRE1α kinase inhibitor with IC50 of 5.9 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 100 mg | Get quote |
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KIRA-8 (AMG-18) is a highly potent, monoselective IRE1α kinase inhibitor with IC50 of 5.9 nM.
KIRA-8 demonstrates higher potency than KIRA7 in inhibiting XBP1 splicing in the alveolar epithelial cell line MLE12, attenuates bleomycin-induced increases in lung weight and hydroxyproline, and decreases mRNA expression of collagen 1A1 and fibronectin in murine model of pulmonary fibrosis.
| M.Wt | 601.122 | |
| Formula | C31H29ClN6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(S)-2-chloro-N-(6-methyl-5-((3-(2-(piperidin-3-ylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-yl)benzenesulfonamide |
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1. Thamsen M, et al. PLoS One. 2019 Jan 9;14(1):e0209824.
2. Morita S, et al. Cell Metab. 2017 Apr 4;25(4):883-897.e8.
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