Catalog No.: PC-38693Not For Human Use, Lab Use Only.
KSI-3716 is a small molecule c-MYC inhibitor that blocks c-MYC/MAX binding to target gene promoters, inhibits c-MYC mediated transcriptional activity at concentrations as low as 1 uM.
KSI-3716 is a small molecule c-MYC inhibitor that blocks c-MYC/MAX binding to target gene promoters, inhibits c-MYC mediated transcriptional activity at concentrations as low as 1 uM.
KSI-3716 markedly decreased the expression of c-MYC target genes, such as cyclin D2, CDK4 and hTERT, exerted cytotoxic effects on bladder cancer cells by inducing cell cycle arrest and apoptosis.
KSI-3716 (5 mg/kg) significantly suppressed tumor growth with minimal systemic toxicity.
KSI-3716 combined with gemcitabine inhibited gemcitabine-resistant cell proliferation to a great extent than each drug alone both in vitro and in vivo.
