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Chemical Structure : KSI-3716
Catalog No.: PC-38693Not For Human Use, Lab Use Only.
KSI-3716 is a small molecule c-MYC inhibitor that blocks c-MYC/MAX binding to target gene promoters, inhibits c-MYC mediated transcriptional activity at concentrations as low as 1 uM.
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KSI-3716 is a small molecule c-MYC inhibitor that blocks c-MYC/MAX binding to target gene promoters, inhibits c-MYC mediated transcriptional activity at concentrations as low as 1 uM.
KSI-3716 markedly decreased the expression of c-MYC target genes, such as cyclin D2, CDK4 and hTERT, exerted cytotoxic effects on bladder cancer cells by inducing cell cycle arrest and apoptosis.
KSI-3716 (5 mg/kg) significantly suppressed tumor growth with minimal systemic toxicity.
KSI-3716 combined with gemcitabine inhibited gemcitabine-resistant cell proliferation to a great extent than each drug alone both in vitro and in vivo.
| M.Wt | 426.091 | |
| Formula | C17H11BrCl2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jeong KC, et al. J Urol. 2014 Feb;191(2):510-8.
2. Seo HK, et al. Oncotarget. 2014 Jan 30;5(2):326-37.
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