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KT-5720

Chemical Structure : KT-5720

CAS No.: 108068-98-0

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KT-5720 (KT5720)

Catalog No.: PC-63046Not For Human Use, Lab Use Only.

KT-5720 (KT5720) is a highly specific PKA (cAMP-dependent protein kinase) inhibitor with Ki of 60 nM, displays little to no activity for MLCK, cGPK, and PKC (Ki>2 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KT-5720 (KT5720) is a highly specific PKA (cAMP-dependent protein kinase) inhibitor with Ki of 60 nM, displays little to no activity for MLCK, cGPK, and PKC (Ki>2 uM).
KT-5720 (KT5720) reversibly arrests human skin fibroblasts in the G1 phase.

Physicochemical Properties

M.Wt 537.605
Formula C32H31N3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, hexyl ester, (9R,10S,12S)-

References

1. Gadbois DM, et al. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8626-30.

2. Feng H, et al. Neuro Oncol. 2015 Jun;17(6):832-42.

3. Ott SR, et al. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):E381-7.

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