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Chemical Structure : KU-177
Catalog No.: PC-72658Not For Human Use, Lab Use Only.
KU-177 (KU-177) is a selective small molecule inhibitor of Hsp90 cochaperone AHSA1 (Aha1 ,activator of Hsp90 ATPase homolog 1, Activator of HSP90 ATPase Activity 1), inhibits interaction between Hsp90 and Aha1.
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KU-177 (KU-177) is a selective small molecule inhibitor of Hsp90 cochaperone AHSA1 (Aha1 ,activator of Hsp90 ATPase homolog 1, Activator of HSP90 ATPase Activity 1), inhibits interaction between Hsp90 and Aha1.
KU-177 inhibits Hsp90-mediated luciferase refolding activity in PC3-MM2 cell with IC50 of 2 uM.
KU-177 inhibits Aha1 enhancement of Hsp90-mediated tau aggregation, increased soluble, phosphorylated tau in cultured cells.
AHSA1-K137 is identified as the site-specific targeting of KU-177 and Bufalin.
KU-177 decreases MM cell proliferation and proteasome inhibitor (PI) resistance induced by AHSA1/HSP90 in vitro (H929 cell IC50=25.8 uM).
KU-177 (1mg/kg, twice per week) extends the survival of 5TMM3VT MM mice when combined with Bortezomib (BTZ) (1mg/kg, twice per week).
| M.Wt | 489.48 | |
| Formula | C27H23NO8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shelton LB, et al. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9707-9712.
2. Gu C, et al. J Exp Clin Cancer Res. 2022 Jan 6;41(1):11.
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