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KW3902

Chemical Structure : KW3902

CAS No.: 136199-02-5

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KW3902 (Rolofylline, KW-3902)

Catalog No.: PC-61328Not For Human Use, Lab Use Only.

Rolofylline (KW3902) is a potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Rolofylline (KW3902) is a potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.
    Rolofylline (KW3902) displays 290-fold selectivity over A2AR.
    Rolofylline (KW3902) antagonizes NECA-induced bradycardic response in anesthetized rats (0.1-1mg/kg), causes significant increases of urine volume and sodium excretion with little change of potassium excretion in saline-loaded normal rats (0.001-1 mg/kg).

    Physicochemical Properties

    M.Wt 356.46
    Formula C20H28N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione

    References

    1. Mizumoto H, et al. J Pharmacol Exp Ther. 1993 Jul;266(1):200-6.

    2. Shimada J, et al. J Med Chem. 1992 Mar 6;35(5):924-30.

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