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Chemical Structure : KY-1220
CAS No.: 292168-79-7
Catalog No.: PC-70091Not For Human Use, Lab Use Only.
KY-1220 is a small molecule destabilizer of both β-catenin and Ras via inhibition of the Wnt/β-catenin pathway (IC50=2.1 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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KY-1220 is a small molecule destabilizer of both β-catenin and Ras via inhibition of the Wnt/β-catenin pathway (IC50=2.1 uM).
KY-1220 dose-dependently decreases Wnt3a-CM-induced TOPflash reporter activation and mRNA expression of Wnt target genes CCND1 and MYC in HEK293 cells.
KY-1220 reduces β-catenin and pan-Ras protein levels via polyubiquitin-dependent proteasomal degradation, consequently inhibits the activities of both ERK and Akt in various CRC cell lines.
KY-1220 efficiently inhibits proliferation and transformation in HCT15, SW480, D-WT and D-MT CRC cells.
| M.Wt | 314.319 | |
| Formula | C14H10N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(Z)-5-((1-(4-nitrophenyl)-1H-pyrrol-2-yl)methylene)-2-thioxoimidazolidin-4-one |
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1. Cha PH, et al. Nat Chem Biol. 2016 Aug;12(8):593-600.
2. Cha PH, et al. BMB Rep. 2016 Sep;49(9):455-6.
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