Chemical Structure : KY-273
CAS No.:
1670224-61-9
KY-273
(KY273)
Catalog No.: PC-22032Not For Human Use, Lab Use Only.
KY-273 (KY273) is a potent, specific CDK8/19 inhibitor with IC50 of 29.1 and 44.7 nM respectively, promotes osteoblast differentiation and has cortical-bone-selective osteogenic effects.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KY-273 (KY273) is a potent, specific CDK8/19 inhibitor with IC50 of 29.1 and 44.7 nM respectively, promotes osteoblast differentiation and has cortical-bone-selective osteogenic effects.
KY-273 displays little effect on CDK2, CDK3, CDK4, CDK5 and CDK6 even at 1000 nM, also has no effect on CDK7 and CDK9 activities.
KY-273 promotes osteoblast differentiation with an increase in alkaline phosphatase (ALP) activity.
KY-273 (0.1-10 uM) concentration- and time-dependently increased ALP activities in ST2 Cells, enhances mRNA expression of Type I collagen.
KY-273 (10 mg/kg/d, p.o. 6 Weeks) increases metaphyseal and diaphyseal Ct.BV, Ct.BMC, and BSPs without affecting medullary volume (Med.V), but doesnot affect Tb.BV and Tb.BMC, in ovaries-intact and ovariectomized rats.
KY-273 increases bone formation rate/bone surface at the periosteal but not the endocortical side, in ovaries-intact and ovariectomized rats.
Physicochemical Properties
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M.Wt
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401.46
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Formula
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C22H27NO6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-4-(1-hydroxyethyl)-3-(4-(2-((tetrahydro-2H-pyran-4-yl)oxy)ethoxy)phenoxy)benzamide
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References
1. Megumi Yamamoto, et al. Biol Pharm Bull. 2024;47(3):669-679.
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