Catalog No.: PC-38661Not For Human Use, Lab Use Only.
L755507 is a potent, selective β3-adrenoceptor (β3-AR) agonist, exhibits robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors (pEC50=12.3), also effectively inhibits the c-Myc-MAX heterodimerization.
L755507 is a potent, selective β3-adrenoceptor (β3-AR) agonist, exhibits robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors (pEC50=12.3), also effectively inhibits the c-Myc-MAX heterodimerization.
L755507 increases phosphorylation of extracellular signal-regulated kinase 1/2 (Erk1/2) with pEC50 of 11.7, couples to both Gs and Gi to activate adenylate cyclase and MAPK signaling.
L755507 efficiently restricts the growth of diverse Myc-expressing cells with low micromolar IC50 values, decreases expression of c-Myc target genes.
L755507 binds to the c-Myc peptide and thereby stabilizes the helix–loop–helix conformation of the c-Myc transcription factor.
