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Chemical Structure : L755507
CAS No.: 159182-43-1
Catalog No.: PC-38661Not For Human Use, Lab Use Only.
L755507 is a potent, selective β3-adrenoceptor (β3-AR) agonist, exhibits robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors (pEC50=12.3), also effectively inhibits the c-Myc-MAX heterodimerization.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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L755507 is a potent, selective β3-adrenoceptor (β3-AR) agonist, exhibits robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors (pEC50=12.3), also effectively inhibits the c-Myc-MAX heterodimerization.
L755507 increases phosphorylation of extracellular signal-regulated kinase 1/2 (Erk1/2) with pEC50 of 11.7, couples to both Gs and Gi to activate adenylate cyclase and MAPK signaling.
L755507 efficiently restricts the growth of diverse Myc-expressing cells with low micromolar IC50 values, decreases expression of c-Myc target genes.
L755507 binds to the c-Myc peptide and thereby stabilizes the helix–loop–helix conformation of the c-Myc transcription factor.
| M.Wt | 584.732 | |
| Formula | C30H40N4O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-4-(3-hexylureido)-N-(4-(2-((2-hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)phenyl)benzenesulfonamide |
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1. Sato M, et al. Mol Pharmacol. 2008 Nov;74(5):1417-28.
2. Hutchinson DS, et al. Br J Pharmacol. 2002 Apr;135(8):1903-14.
3. Singh A, et al. J Biol Chem. 2021 Jul;297(1):100903.
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