Chemical Structure : LTI-291
CAS No.: 1919820-28-2
Catalog No.: PC-24167Not For Human Use, Lab Use Only.
Pariceract (LTI-291) is an allosteric, CNS-penetrable glucosylceramidase beta (glucocerebrosidase, GCase) activator.
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Pariceract (LTI-291) is an allosteric, CNS-penetrable glucosylceramidase beta (glucocerebrosidase, GCase) activator.
Pariceract (LTI-291) at concentrations of 0.1 and 1.0 μM increases wild type GCase activity by 25% and 130%, respectively.
Pariceract (LTI-291) shows potential for parkinson's disease carrying a GBA1 mutation.
M.Wt | 358.49 | |
Formula | C20H30N4O2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
5,7-dimethyl-N-[trans-4-(pentyloxy)cyclohexyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide |
1. den Heijer JM, et al. Br J Clin Pharmacol. 2021 Sep;87(9):3561-3573.
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