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LTI-291

Chemical Structure : LTI-291

CAS No.: 1919820-28-2

LTI-291 (Pariceract)

Catalog No.: PC-24167Not For Human Use, Lab Use Only.

Pariceract (LTI-291) is an allosteric, CNS-penetrable glucosylceramidase beta (glucocerebrosidase, GCase) activator.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Pariceract (LTI-291) is an allosteric, CNS-penetrable glucosylceramidase beta (glucocerebrosidase, GCase) activator.
Pariceract (LTI-291) at concentrations of 0.1 and 1.0 μM increases wild type GCase activity by 25% and 130%, respectively.
Pariceract (LTI-291) shows potential for parkinson's disease carrying a GBA1 mutation.

Physicochemical Properties

M.Wt 358.49
Formula C20H30N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5,7-dimethyl-N-[trans-4-(pentyloxy)cyclohexyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

References

1. den Heijer JM, et al. Br J Clin Pharmacol. 2021 Sep;87(9):3561-3573.

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