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LY-2119620

Chemical Structure : LY-2119620

CAS No.: 886047-22-9

LY-2119620 (LY 2119620;LY2119620)

Catalog No.: PC-60326Not For Human Use, Lab Use Only.

LY 2119620 is a potent, specific,positive allosteric modulator of muscarinic M2 and M4 receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LY 2119620 is a potent, specific,positive allosteric modulator of muscarinic M2 and M4 receptors.
LY 2119620 displays inimal allosteric agonism for M1, M3, M5 receptors.
LY 2119620 enhances the potency of three muscarinic acetylcholine receptor agonists, ACh, Oxo-M and Iperoxo.

Physicochemical Properties

M.Wt 437.94
Formula C19H24ClN5O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-Amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy] thieno[2,3-b]pyridine-2-carboxamide

References

1. Kruse AC, et al. Nature. 2013 Dec 5;504(7478):101-6.

2. Croy CH, et al. Mol Pharmacol. 2014 Jul;86(1):106-15.

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