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LY-2584702

Chemical Structure : LY-2584702

CAS No.: 1082949-67-4

LY-2584702 (LY2584702)

Catalog No.: PC-43058Not For Human Use, Lab Use Only.

LY2584702 is a potent, selective, ATP-competitive inhibitor of P70 S6 kinase-1 (p70S6K1) with IC50 of 4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LY2584702 is a potent, selective, ATP-competitive inhibitor of P70 S6 kinase-1 (p70S6K1) with IC50 of 4 nM.
LY2584702 blocks phosphorylation of p70S6K in primary rat hepatocytes without affecting the phosphorylation of other signaling kinases, including GSK-3β and ERK1/2.
LY2584702 inhibits phosphorylation of p70S6K in HCT116 colon cancer cells with IC50 of 0.1-0.24 uM, demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models.

Physicochemical Properties

M.Wt 445.4161
Formula C21H19F4N7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 4.5 mg/mL

Chemical Name/SMILES

1H-Pyrazolo[3,4-d]pyrimidine, 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-

References

1. Estridge TB, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):108-118.

2. Tolcher A, et al. Eur J Cancer. 2014 Mar;50(5):867-75.

3. Hollebecque A, et al. Eur J Cancer. 2014 Mar;50(5):876-84.

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