You are here:Home-Chemical Inhibitors & Agonists-Ras-Raf-MAPK-ERK Pathway-Ribosomal S6 Kinase (RSK)-LY-2584702 tosylate
LY-2584702 tosylate

Chemical Structure : LY-2584702 tosylate

CAS No.: 1082949-68-5

LY-2584702 tosylate (LY-2779964, LY2584702, LY2779964)

Catalog No.: PC-43059Not For Human Use, Lab Use Only.

LY-2779964 (LY2584702 tosylate) is a potent, selective, ATP-competitive inhibitor of P70 S6 kinase-1 (p70S6K1) with IC50 of 4 nM.

Packing Price Stock Quantity
5 mg $78 In stock
10 mg $108 In stock
25 mg $198 In stock
50 mg $298 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LY-2779964 (LY2584702 tosylate) is a potent, selective, ATP-competitive inhibitor of P70 S6 kinase-1 (p70S6K1) with IC50 of 4 nM.
LY2584702 tosylate blocks phosphorylation of p70S6K in primary rat hepatocytes without affecting the phosphorylation of other signaling kinases, including GSK-3β and ERK1/2.
LY2584702 tosylate inhibits phosphorylation of p70S6K in HCT116 colon cancer cells with IC50 of 0.1-0.24 uM.
LY2584702 tosylate demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models.

Physicochemical Properties

M.Wt 617.6177
Formula C28H27F4N7O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 10.25 mg/mL

Chemical Name/SMILES

1H-Pyrazolo[3,4-d]pyrimidine, 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-, 4-methylbenzenesulfonate (1:1)

References

1. Estridge TB, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):108-118.

2. Tolcher A, et al. Eur J Cancer. 2014 Mar;50(5):867-75.

3. Hollebecque A, et al. Eur J Cancer. 2014 Mar;50(5):876-84.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: