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Leukadherin 1

Chemical Structure : Leukadherin 1

CAS No.: 344897-95-6

Leukadherin 1 (LA1)

Catalog No.: PC-60253Not For Human Use, Lab Use Only.

Leukadherin 1 (LA1) is a small molecule allosteric agonist of integrin CD11b/CD18 (CR3), increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50=4 uM).

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Biological Activity

Leukadherin 1 (LA1) is a small molecule allosteric agonist of integrin CD11b/CD18 (CR3), increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50=4 uM); reduces IFN-I responses in WT but not CD11b-deficient mice, and protects lupus-prone MRL/Lpr mice from end-organ injury; reduces TLR-dependent proinflammatory signaling in leukocytes and suppresses IFN-I signaling via an AKT/FOXO3/IFN regulatory factor 3/7 pathway.

Physicochemical Properties

M.Wt 421.49
Formula C22H15NO4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-[(5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]benzoic acid

References

1. Celik E, et al. Biophys J. 2013 Dec 3;105(11):2517-27.

2. Jagarapu J, et al. Am J Respir Cell Mol Biol. 2015 Dec;53(6):793-801.

3. Czirr E, et al. J Exp Med. 2017 Apr 3;214(4):1081-1092.

4. Roberts AL, et al. Clin Exp Immunol. 2016 Sep;185(3):361-71.

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