You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-Lotamilast
Lotamilast

Chemical Structure : Lotamilast

CAS No.: 947620-48-6

Lotamilast (RVT 501;E6005)

Catalog No.: PC-61387Not For Human Use, Lab Use Only.

Lotamilast (RVT 501, E6005) is a potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM.

Packing Price Stock Quantity
5 mg $98 In stock
10 mg $138 In stock
25 mg $218 In stock
50 mg $378 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Lotamilast (RVT 501, E6005) is a potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM.
Lotamilast (RVT 501, E6005) produces an immediate antipruritic effect as well as an anti-inflammatory effect with reduced expression of cytokines/adhesion molecules in mice after topical application.
Lotamilast (RVT 501, E6005) ameliorates the appearance of atopic dermatitis-like skin lesions in AD models.

Physicochemical Properties

M.Wt 472.501
Formula C26H24N4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate

References

1. Ishii N, et al. J Pharmacol Exp Ther. 2013 Jul;346(1):105-12.

2. Andoh T, et al. Exp Dermatol. 2014 May;23(5):359-61.

3. Kubota S, et al. Eur J Pharmacol. 2015 Dec 5;768:41-8.

4. Furue M, et al. Expert Opin Investig Drugs. 2017 Dec;26(12):1403-1408.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: