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Lotamilast

Chemical Structure : Lotamilast

CAS No.: 947620-48-6

Lotamilast (RVT 501;E6005)

Catalog No.: PC-61387Not For Human Use, Lab Use Only.

Lotamilast (RVT 501, E6005) is a potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Lotamilast (RVT 501, E6005) is a potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM.
Lotamilast (RVT 501, E6005) produces an immediate antipruritic effect as well as an anti-inflammatory effect with reduced expression of cytokines/adhesion molecules in mice after topical application.
Lotamilast (RVT 501, E6005) ameliorates the appearance of atopic dermatitis-like skin lesions in AD models.

Physicochemical Properties

M.Wt 472.501
Formula C26H24N4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate

References

1. Ishii N, et al. J Pharmacol Exp Ther. 2013 Jul;346(1):105-12.

2. Andoh T, et al. Exp Dermatol. 2014 May;23(5):359-61.

3. Kubota S, et al. Eur J Pharmacol. 2015 Dec 5;768:41-8.

4. Furue M, et al. Expert Opin Investig Drugs. 2017 Dec;26(12):1403-1408.

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