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M-110

Chemical Structure : M-110

CAS No.: 1395048-49-3

M-110 (M110)

Catalog No.: PC-43239Not For Human Use, Lab Use Only.

M-110 is a potent, selective inhibitor of PIM kinase family with preference for PIM-3 with IC50 of 0.047, 2.5 and 2.5 uM for PIM3, PIM1 and PIM2, respectively.

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5 mg $128 In stock
10 mg $188 In stock
25 mg $328 In stock
50 mg $528 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

M-110 is a potent, selective inhibitor of PIM kinase family with preference for PIM-3 with IC50 of 0.047, 2.5 and 2.5 uM for PIM3, PIM1 and PIM2, respectively.
M-110 dispplays excellent selectivity in a panel of 261 kinases.
M-110 inhibits the growth of DU-145 cells with IC50 of 0.9 uM, significantly reduces pSTAT3(Tyr705) expression without affecting the expression of STAT3.
M-110 also attenuates the IL-6-induced increase in pSTAT3(Tyr705), shows no effect on phosphorylation of STAT5 on Tyr694 in 22Rv1 cells.

Physicochemical Properties

M.Wt 445.9424
Formula C22H28ClN5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-Pyridinecarboxylic acid, 2-[[3-(4-morpholinyl)propyl]amino]-, 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide

References

1. Chang M, et al. Mol Cancer Ther. 2010 Sep;9(9):2478-87.

2. Siu A, et al. Oncotarget. 2011 Dec;2(12):1134-44.

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