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Chemical Structure : M-110
CAS No.: 1395048-49-3
Catalog No.: PC-43239Not For Human Use, Lab Use Only.
M-110 is a potent, selective inhibitor of PIM kinase family with preference for PIM-3 with IC50 of 0.047, 2.5 and 2.5 uM for PIM3, PIM1 and PIM2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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M-110 is a potent, selective inhibitor of PIM kinase family with preference for PIM-3 with IC50 of 0.047, 2.5 and 2.5 uM for PIM3, PIM1 and PIM2, respectively.
M-110 dispplays excellent selectivity in a panel of 261 kinases.
M-110 inhibits the growth of DU-145 cells with IC50 of 0.9 uM, significantly reduces pSTAT3(Tyr705) expression without affecting the expression of STAT3.
M-110 also attenuates the IL-6-induced increase in pSTAT3(Tyr705), shows no effect on phosphorylation of STAT5 on Tyr694 in 22Rv1 cells.
| M.Wt | 445.9424 | |
| Formula | C22H28ClN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-Pyridinecarboxylic acid, 2-[[3-(4-morpholinyl)propyl]amino]-, 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide |
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1. Chang M, et al. Mol Cancer Ther. 2010 Sep;9(9):2478-87.
2. Siu A, et al. Oncotarget. 2011 Dec;2(12):1134-44.
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