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M-443

Chemical Structure : M-443

CAS No.: 1820684-31-8

M-443 (M443;M 443)

Catalog No.: PC-70175Not For Human Use, Lab Use Only.

M-443 (M443) is a specific, irreversible inhibitor of MLK-related kinase MRK (ZAK), does not inhibit Bcr-Abl.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

M-443 (M443) is a specific, irreversible inhibitor of MLK-related kinase MRK (ZAK), does not inhibit Bcr-Abl.
M-443 effectively inhibits MRK downstream signals in primary medulloblastoma cells and prevents cell-cycle arrest induced by IR.
M-443 also inhibits radiation-induced activation of both p38 and Chk2.
M-443 achieves a synergistic increase in survival in an animal model of medulloblastoma.

Physicochemical Properties

M.Wt 589.623
Formula C31H30F3N7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-((4-(1-acryloylpiperidin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

References

1. Markowitz D, et al. Mol Cancer Ther. 2016 Aug;15(8):1799-808.

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