Chemical Structure : M6766
CAS No.:
696628-90-7
M6766
(M-6766)
Catalog No.: PC-25115Not For Human Use, Lab Use Only.
M6766 is a potent, selective inhibitor of endoplasmic reticulum oxidoreductase 1α (ERO1α) with IC50 of 1.4 uM and KD of 1.1 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
M6766 is a potent, selective inhibitor of endoplasmic reticulum oxidoreductase 1α (ERO1α) with IC50 of 1.4 uM and KD of 1.1 uM.
M6766 exhibits >70-fold selectivity over other tested enzymes, except ERO1β (IC50=7.2 μM).
M6766 binds to the FAD-binding pocket in ERO1α.
M6766 concentration-dependently inhibits granule secretion, αIIbβ3 integrin activation, Ca2+ mobilization, and platelet aggregation induced by various agonists, but it does not affect agonist-induced production of reactive oxygen species.
M6766 diminishes platelet accumulation on collagen-coated surfaces under arterial shear conditions.
M6766 decreases arterial thrombosis and infarct volume during ischemic stroke without prolonging tail bleeding times in mice.
Physicochemical Properties
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M.Wt
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360.44
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Formula
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C19H16N6S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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11-((4-methyl-4H-1,2,4-triazol-3-yl)thio)-7,8,9,10-tetrahydrobenzo[4,5]imidazo[1,2-b]isoquinoline-6-carbonitrile
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References
1. Wang J, et al. Mol Ther. 2025 Jul 23:S1525-0016(25)00569-6.
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