Chemical Structure : MDI-114215
CAS No.:
MDI-114215
(MDI 114215)
Catalog No.: PC-23696Not For Human Use, Lab Use Only.
MDI-114215 is a potent, allosteric, and highly selective dual-LIMK1/2 inhibitor with IC50 of 20/27 nM respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MDI-114215 is a potent, allosteric, and highly selective dual-LIMK1/2 inhibitor with IC50 of 20/27 nM respectively.
MDI-114215 inhibits PAK1-phosphorylated LIMK1/2 activity with pIC50 of 7.89 and 7.96, and reduces cellular p-cofilin levels in the AlphaLISA assay.
MDI-114215 does not bind TESK1, a close neighbor that is a member of the TKL kinase family, nor to CaMKIV, MRCKα, PAK1–2/4 or ROCK1/2.
MDI-114215 decreases phosphorylated cofilin levels ex vivo and reverses the deficit in LTP of mouse Fmr1 KO hippocampal CA1 pyramidal neurons.
MDI-114215 reverses hippocampal LTP deficits in a mouse model of FXS, potently decreases phosphorylated cofilin levels in iPSC-derived neurons from FXS patients.
Physicochemical Properties
|
M.Wt
|
479.60
|
|
Formula
|
C26H29N3O4S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N-(Cyclopropylmethyl)-N-[[4-(2-hydroxyethylamino)phenyl]methyl]-4-(phenylsulfamoyl)benzamide
|
References
1. Baldwin AG, et al. J Med Chem. 2024 Dec 22. doi: 10.1021/acs.jmedchem.4c02694.
Contact Us
sales@probechem.com
