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Chemical Structure : MG-132
CAS No.: 133407-82-6
Catalog No.: PC-43439Not For Human Use, Lab Use Only.
MG-132 (Z-Leu-leu-leu-al, Zlllal) is a potent, reversible, and cell-permeable proteasome inhibitor with IC50 of 0.1 and 1.2 μM for the inhibition of proteasome and calpain, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $68 | In stock | |
| 50 mg | $148 | In stock | |
| 100 mg | $228 | In stock | |
| 250 mg | $378 | In stock | |
| 1 g | Get quote |
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MG-132 (Z-Leu-leu-leu-al, Zlllal) is a potent, reversible, and cell-permeable proteasome inhibitor with IC50 of 0.1 and 1.2 μM for the inhibition of proteasome and calpain, respectivel.
MG-132 induces neurite outgrowth in PC12 cells with optimal concentrations of 20 nM.
MG-132 inhibits autolytic activation of calpain in rabbit erythrocytes at 100 uM; demonstrates in vivo antitumor activity.
| M.Wt | 475.62 | |
| Formula | C26H41N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]- |
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1. Tsubuki S, et al. J Biochem. 1996 Mar;119(3):572-6.
2. Tsubuki S, et al. Biochem Biophys Res Commun. 1993 Nov 15;196(3):1195-201.
3. Palombella VJ, et al. Cell. 1994 Sep 9;78(5):773-85.
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