Catalog No.: PC-24270Not For Human Use, Lab Use Only.
MI202 is a potent inhibitor of MYCN expression, inhibits both MYCN promoter activity (IC50=2.21 μM) and endogenous MYCN expression (IC50=1.07 μM) in JHH7 cells, through ACOT2-mediated signaling pathways.
MI202 is a potent inhibitor of MYCN expression, inhibits both MYCN promoter activity (IC50=2.21 μM) and endogenous MYCN expression (IC50=1.07 μM) in JHH7 cells, through ACOT2-mediated signaling pathways. MI202 also suppressed MYCN protein expression in a time- and dose-dependent manner. MI202 also reduced cell viability in JHH7 cells, both in monolayer (IC50 = 2.46 μM) and spheroid (IC50 = 1.55 μM) cultures, while no effects were observed in Hc cells (IC50 > 10 μM, respectively). MI202 suppressed the expression of the cell cycle regulator cyclin B1 and upregulated the expression of the cyclin-dependent kinase inhibitor p15Ink4b in JHH7 cells. MI202 induced apoptosis in JHH7 cells in a time- and dose-dependent manner. MI202 significantly downregulated ACOT2 expression in JHH7 cells.
Physicochemical Properties
M.Wt
228.27
Formula
C12H8N2OS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1-benzothiazol-2-yl-1h-pyrrole-2-carbaldehyde
References
1. Xu Y, et al. Front Oncol. 2025 Feb 14;15:1486671.
