MI 219 |CAS:908027-55-4 Probechem Biochemicals

Chemical Structure : MI 219

MI 219 (MI219, MI-219)

Catalog No.: PC-62086Not For Human Use, Lab Use Only.

MI 219 is a potent, specific MDM2-p53 inhibitor with Ki of 5 nM, >10,000-fold selective for MDM2 over MDMX.

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Biological Activity

MI 219 is a potent, specific MDM2-p53 inhibitor with Ki of 5 nM, >10,000-fold selective for MDM2 over MDMX.
MI 219 disrupts the MDM2-p53 interaction and activates the p53 pathway in cells with wild-type p53, which leads to induction of cell cycle arrest in all cells and selective apoptosis in tumor cells.
MI 219 inhibits tumor growth in mouse xenograft models.

Physicochemical Properties

M.Wt	552.468
Formula	C27H32Cl2FN3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2'R,3S,4'R,5'R)-6-Chloro-4'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-2'-(2,2-dimethylpropyl)-5-fluoro-1,2-dihydro-2-oxospiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide

References

1. Shangary S, et al. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3933-8.

2. Peterson LF, et al. Leukemia. 2011 May;25(5):761-9.

3. Feng FY, et al. Neoplasia. 2016 Apr;18(4):213-22.

MI 219 (MI219, MI-219)

Biological Activity

Physicochemical Properties

References

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