Chemical Structure : MK-3207 (Hydrochloride)
CAS No.:
957116-20-0
MK-3207 (Hydrochloride)
(MK3207 Hydrochloride;MK 3207 Hydrochloride;MK-3207)
Catalog No. : PC-42517Not For Human Use, Lab Use Only.
A highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay.
Packing Price Stock Quantity 10 mg $208 In stock 0 1 2 3 4 5 50 mg $640 In stock 0 1 2 3 4 5 100 mg $968 In stock 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4251701
Biological Activity
A highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay; displays >50000-fold selectivity in a panel of 160 enzymes, receptors, channels, and 65-fold more potent than telcagepant; orally bioavailable.
Physicochemical Properties
M.Wt
594.0514
Formula
C31H30ClF2N5O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
6,9-Diazaspiro[4.5]decane-9-acetamide, 8-(3,5-difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-, hydrochloride (1:1), (8R)-
References
1. Bell IM, et al. ACS Med Chem Lett. 2010 Jan 12;1(1):24-9.
2. Salvatore CA, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60.
3. Li CC, et al. Br J Clin Pharmacol. 2015 May;79(5):831-7.
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