Chemical Structure : MK-4827 tosylate
CAS No.: 1038915-73-9
Catalog No.: PC-42683Not For Human Use, Lab Use Only.
A highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2.
Packing | Price | Stock | Quantity |
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10 mg | $120 | In stock | |
50 mg | $320 | In stock | |
100 mg | $520 | In stock |
Bulk size, bulk discount!
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A highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2; inhibits PARP activity with EC50=4 nM in a whole cell assay, and inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10−100 nM range; well tolerated in vivo and demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer.
Ovarian Cancer
Approved
M.Wt | 492.5899 | |
Formula | C26H28N4O4S | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO: ≥ 490 mg/mL |
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Chemical Name/SMILES |
2H-Indazole-7-carboxamide, 2-[4-(3S)-3-piperidinylphenyl]-, 4-methylbenzenesulfonate (1:1) |
1. Jones P, et al. J Med Chem. 2009 Nov 26;52(22):7170-85.
2. Bridges KA, et al. Oncotarget. 2014 Jul 15;5(13):5076-86.
3. Mirza MR, et al. N Engl J Med. 2016 Dec 1;375(22):2154-2164.
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