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Chemical Structure : ML-213
CAS No.: 489402-47-3
Catalog No.: PC-60228Not For Human Use, Lab Use Only.
ML213 is a novel potent, selective KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) activator with EC50 of 230 and 510 nM, respectively.
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|---|---|---|---|
| 25 mg | $258 | In stock | |
| 100 mg | $598 | In stock | |
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| 1 g | Get quote |
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ML213 is a novel potent, selective KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) activator with EC50 of 230 and 510 nM, respectively.
ML213 displays >80-fold selectivity over other related potassium channels (KCNQ1/3/5).
ML213 causes significant hyperpolarization in mesenteric artery smooth muscle cells, shows potent vasorelaxant effects in different blood vessels.
| M.Wt | 257.37 | |
| Formula | C17H23NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide |
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1. Yu H, et al. ACS Chem Neurosci. 2011 Oct 19;2(10):572-577.
2. Jepps TA, et al. Br J Pharmacol. 2014 Oct;171(19):4413-24.
3. Brueggemann LI, et al. Mol Pharmacol. 2014 Sep;86(3):330-41.
4. Provence A, et al. J Pharmacol Exp Ther. 2017 Oct 30. pii: jpet.117.243162.
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